A man who was reportedly armed with a handgun and tried to attack police officers as he shouted "Allah Akbar" (God is greatest) has been shot dead.
The man is also reported to have tried to attack passers-by in the street on Thursday around 11.15am in Montfavet, near the city of Avignon in southern France, Europe 1 reports.
Public prosecutor Philippe Guémas confirmed that the man "had been threatening passers-by when police intervened" in the Montfavet district of the city.
The attacks started around 11am – two hours after the one in Nice.
Authorities reported the suspect in Avignon succumbed to his injuries and an investigation has been launched.
"The man charged at them with his weapon and was killed by the police," Provence reports being told by a spokesperson for the Avignon police.
"There are no injuries.
"All avenues are being considered, but for the moment we do not have an Islamist character."
It comes just hours after at least three people died and several others were injured after a knife attack inside the Notre-Dame church in Nice in a suspected terrorist attack.
A person of around 70 years old was reportedly beheaded inside the Notre-Dame basilica and another person lost their life inside the church.
Avignon is 150 miles away from Nice.
British Prime Minister Boris Johnson has condemned the "barbaric" Nice attack and said the UK "stands steadfastly with France against terror and intolerance".
A man has also been arrested after he stabbed a guard at the French Consulate in Jiddah, Saudi Arabia’s state-run news agency said.
It is currently unclear if the attacks are related.
The attacks come while France is still reeling from the beheading earlier this month of French middle school teacher Samuel Paty in Paris by a man of Chechen origin.
The attacker had said he wanted to punish Paty for showing pupils cartoons of the Prophet Mohammad in a civics lesson.
It was not immediately clear what the motive was for the Nice and Avignon attacks, or if there was any connection to the cartoons, which Muslims consider to be blasphemous.
Since Paty's killing, French officials - backed by many ordinary citizens - have re-asserted the right to display the cartoons, and the images have been widely displayed at marches in solidarity with the killed teacher.
That has prompted an outpouring of anger in parts of the Muslim world, with some governments accusing French leader Emmanuel Macron of pursuing an anti-Islam agenda.