The Prime Minister appeared on BBC One's The Andrew Marr Show on Sunday, October 4, and warned Brits about the battles the country faces as it tries to overcome the deadly coronavirus.
He highlighted the country's obesity problem, saying his own weight had been one of the issues that contributed to his diagnosis with the virus earlier this year, saying it could be a "teachable moment" for fellow Brits who are also overweight.
The Prime Minister also said he knew the public was "furious with me and the Government" over the lockdown measures but insisted they were necessary.
In an interview with the BBC, Mr Johnson said: "I appreciate the fatigue that people are experiencing... but we have to work together, follow the guidance and get the virus down whilst keeping the economy moving."
He went on: "They're furious at me and they're furious for the Government, but... I've got to tell you in all candour it's going to continue to be bumpy through to Christmas, it may even be bumpy beyond.
"But this is the only way to do it."
Mr Johnson said the country needed to face the fact that it could be "a very tough winter".
However he insisted that Britons should behave "fearlessly" but with "common sense", as he set out the need to balance controlling coronavirus and protecting the economy.
He also said the pandemic had brought home that the UK was "slightly too fat".
Obesity has been identified as a risk factor for those who contract Covid-19.
He added: "The issue is when I got this wretched thing I was, alas, too fat.
"If I may say so, this is a teachable moment for our great country because we are one of the greatest places on Earth but, alas, as a nation we are slightly too fat.
"We are fatter than virtually anybody else in Europe, apart from the Maltese for some reason, and we need to think about this.
"I don't wish to cast any aspersions on my Maltese friends."
When asked if he would advise US President Donald Trump, who was hospitalised with the illness on Friday to "eat a few less cheeseburgers" following his comments, the PM added: "I'm not making any comment about President Trump, but obesity, since you mention cheeseburgers, is one of the problems that this country needs to address.
"Not just because it threatens all our health but in the long term we need to tackle it to reduce the pressures on the NHS. It costs us all a fortune in taxation to cope with it."