Students in the university cities of in Portsmouth and Exeter were seen in large crowds on Tuesday night as the drinks flowed.
Freshers in Portsmouth queued in their droves to get into venues, ready for a wild night out on the town.
Some were later seen mingling in the street after they left the sitting-only nightclubs – or even being carried home by pals.
One excited reveller even picked up a road cone during his night out.
Campus security guards at Exeter University have been moving students back into their rooms after they were spotted partying outside some of the most expensive accommodation.
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But one student who took photographs say the gatherings are happening every night and as soon as security guards leave, the party begins again.
They say the parties involve between 300 and 400 students and go on until 3am, DevonLive reports.
Some students are upset that the partying is going on despite the new rule of six government law.
The new rule means it is now illegal for people in England to meet in groups of more than six, inside or outside, following a rise of coronavirus cases.
One unhappy student said there have been huge nightly gatherings outside her room as she tried to study.
She shared a WhatsApp group chat that says tonight will be "bigger and better" with a DJ bringing loud music.
She said for two nights: "None of them are wearing masks and social distancing isn't happening. They were being quite stubborn and refused to go back into their rooms for quite a long time.
"I have parents with underlying health problems and family in Devon and know that the Royal Devon and Exeter Hospital is overstretched enough.
"None of them seem to care about giving the virus to each other or to local people in the community.
"They are also sharing on the group chat about how to sneak in to Wetherspoons and avoid the Track and Trace."
A spokesperson for the University of Exeter said: “Students are required and expected to adhere to Government laws and guidelines on Covid-19.
"The University is, and remains, in regular contact with all students and staff to relay the latest Government information, and remind them of the necessity to follow these rules fully.
"The University, police and local authorities are sharing information and coordinating their response based on any reports received.”