Cosmetics giant Estée Lauder is paying £100,000 to send ten bottles of its Advanced Night Repair serum 250 miles above Earth.
ISS astronauts will take snaps and film each other posing with the bottles in weightless conditions for four hours as part of the deal.
A spokesman for the US space agency said Estée Lauder was "paying for the astronauts to be the photographer, not to use the product, not to put the product on themselves, not even to open the product".
Meanwhile the revenue from commercial deals will help repay a fraction of the estimated £3billion cost of operating the ISS.
The space agency's Phil McAlister said: "NASA is opening the International Space Station to business as part of the agency’s efforts to enable a robust low-Earth orbit economy."
It comes as NASA officially outlined its £22bn plan to put a man and the first woman on the moon by 2024.
The Artemis mission will be the first time any humans have set foot on the lunar surface since the last Apollo lunar mission in 1972.
In order for the plans to go ahead, NASA requires the US Congress to release $3.2bn in order for a landing system to be built.
Astronauts will travel in an Apollo-like capsule called Orion that will launch on a powerful rocket called the Space Launch System (SLS).
Speaking on Monday afternoon (US time), Nasa administrator Jim Bridenstine said: "The $28bn represents the costs associated for the next four years in the Artemis programme to land on the Moon. SLS funding, Orion funding, the human landing system and of course the spacesuits - all of those things that are part of the Artemis programme are included."