The Queen of Reality TV tied the knot with the controversial rapper in 2014 before having four children, North, Saint, Psalm and Chicago together.
But now, Page Six report Kim is 'done' with the marriage and has spoken to lawyers about potential divorce terms.
A source told the US publication: "Kim got Kanye to go [to Wyoming over Christmas] so they could live separate lives and quietly get things sorted out to separate and divorce. She’s done.
"Now this divorce is happening because Kim has grown up a lot.
"She is serious about taking the bar exam and becoming a lawyer, she is serious about her prison reform campaign.
"Meanwhile Kanye is talking about running for president and saying other crazy s*** and she’s just had enough of it."
Here we run down some of the most explosive moments from Kim and Kanye's very public romance.
Kim and Meek Mill's meeting
When Kim was pregnant with her first child North she is said to have met with rapper Meek Mill infuriating her hubby.
While the meeting was said to have taken place at the Waldorf Hotel in 2018 to discuss Kim's move into becoming a lawyer.
In July 2020 Kanye aired his issues with the meeting ranting on Twitter: "I been trying to get divorced since Kim met with Meek at the Warldolf for "prison reform"...
"Meek is my man and was respectful... That's my dog... Kim was out of line...
"I'm worth 5 billion dollars and more than that through Christ... But ya'll ain't listen to MJ and now ya'll believe them???"
Meek strongly denied the meeting was anything but platonic.
Kris Jenner rows
Kanye has long been reported to have taken umbrage with Kim Kardashians momager mother Kris Jenner.
Countless repairs claimed Kris and Kayne didn't always see eye to eye but it wasn't until Kanye likened her to the leader of North Korea that fans really new there was bad blood.
Mocking Kris, who is said to be the mastermind behind all her daughter's careers, Yeezy branded his mother-in-law Kris Jong-Un.
In a concerning meltdown on July 21 last year, Kanye raged: "They tried to fly in with 2 doctors to 51/50 me....
"This my lady tweet of the night... Kris Jong-Un. Lil baby by favorite rapper but won't do a song wit me [sic]."
Kanye's shock abortion rant
During his ill-fated Presidential campaign, Kanye told his fans how he had considered aborting his and Kim's first daughter North.
The rapper appeared on stage at a small rally during the summer of 2020 before making the claims.
Kanye said: "I remember that my girlfriend called me screaming and crying, and I was just thinking, because at that time I was a rapper I was out there, [had] different girlfriends and everything ... and she said, 'I'm pregnant.' And I said, 'Yes!' And then I said, ‘Uh oh.' "
"She was crying … and for one month and two months and three months, we talked about her not having this child. She had the pills in her hand."
He continued: "I called my wife and she said, ‘We’re gonna have this baby,’ and I said ‘We’re gonna have this child.'"
Living apart but still together
Widespread reports throughout lockdown claimed that Kim and Kanye didn't live together for a large section of 2020.
Initially it was alleged that the strained couple were living at each ends of their home and had taken up separate lives.
A source told The Sun: "Kim and Kanye are arguing and at each other's throats during this pandemic.
"Kim is getting stir crazy, as she's used to being on the go. It's also a lot of time alone with the kids for her.
"She is frustrated with Kanye and thinks he's not pulling his weight in family responsibilities.
"They've been staying at opposite ends of the house to keep things civil."
Later in the year it was claimed Kanye moved to Wyoming while Kim stayed in Los Angeles.
An insider told HollywoodLife: “Kim and Kanye are struggling to stay together as a couple and have for quite some time now.
“They really are living separate lives right now and have for awhile.”
Meanwhile, a source added E! News that the couple planned to spend Christmas Eve together.
They said: "It won't be like years past, but they will do something as a family and all be together."