The Good Morning Britain host has been very vocal of his feelings towards his one-time acquaintance Meghan, 39, and is sharpening his claws again with his latest takedown.
The 55-year-old said: "The endless videos where he sits or stands by her side looking slightly vacant-eyed remind me of hostage videos each time they appear – she does most of the talking and he's like a nodding puppet.
"It's almost like she's got some robotic mechanism which makes his mouth move but the whole thing is just very sad."
Piers said his feelings towards Meghan soured after she was "quite rude" to him, as he claimed she snubbed him after he gave her and a former Suits co-star some media advice.
He told Australia's Daily Telegraph: "I was giving her media advice and another member of the cast of Suits and she asked if she could come and have a drink with me at my local pub and we met up and we had a really good time, and I thought she was really nice actually.
"And then I literally put her in a cab to a dinner that she was going to and she met Harry at that dinner, and I never heard from her again. I thought that was quite rude."
Meghan and Harry, 34, are often the targets of Piers' rants on Good Morning Britain and online – but he has said he's not a bully, he's just calling things out as he sees them.
Recently, he slammed the couple and said they should be stripped of all of their royal titles after they both appeared in a video urging US citizens to vote in the upcoming Presidential Election.
He claimed the video implied they were suggesting viewers should vote for Joe Biden, when members of the Royal Family should be politically neutral.
While Harry and Meghan have cut ties with their royal duties, they still have a number of official titles.