Not only were the Catalan giants soundly beaten in the quarter-final stages, but they were truly embarrassed by a Bayern Munich side that would score four goals in each half while conceding just twice.
In another blow for Barcelona, their own player would play a part in three of those goals in Philippe Coutinho, who came off the bench to score twice and lay on an assist for Robert Lewandowski.
In a moment that would go on to sum up the match, Barcelona hero Messi was spotted looking out of ideas at the break after the Bundesliga champions raced into what would prove to be a insurmountable lead.
The 33-year-old, who has made no secret of his issues with the hierarchy at the club across the last year, was pictured on Twitter looking desolate as he waited for the second period to begin.
Although Messi created several chances for his team-mates before the break, their only goal came from a calamitous mistake by the usually reliable defender David Alaba.
Messi would go on to play the full match as Bayern ran riot at the Search Results Estadio da Luz in Portugal, which ended his hopes of any team silverware in 2019/20.
Although the world's best playmaker still has plenty to offer on the pitch, he is yet to comment over his future as he approaches the final stages of a glittering career.
In a another blow for under fire boss Quique Setien, some Bayern players were far from modest in their success.
Leon Goretzka said after the match when asked if it hurt to embarrass Messi: "No, it didn’t hurt, it was fun actually."
"It’s difficult to put this into words so soon after the game. I think it will take a couple of days to process this result.
"We have so much confidence, but as we just said in the changing room we've taken the first of three steps."
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With Thomas Muller adding: ”We feel good, but now we have to be quiet and regenerate.
"This is a big statement but the next game we start at 0-0. The statement doesn't matter. The other teams will watch our game and they can be impressed or not. We start at 0-0 and have to win the next game.
"Today we have to be very happy. After we wake up and answer the messages on the phone then we have to focus.
"I know about these tournament situations. Most of the time after the big wins ( having played in the 7-1 win over Brazil in 2014) it's difficult."