Cristiano Ronaldo has suffered from an infection that is believed to have come from a bee sting.
The Juventus forward is currently with his national squad as Portugal prepare to take on Croatia in the Nations League.
However, the five-time Ballon d'Or winner has missed out on the last few training sessions.
It comes as a result of Ronaldo insisting he has been in agonising pain.
The 35-year-old rarely misses out on training and remains in impeccable shape.
So it came as a surprise to Portugal boss Fernando Santos, who has revealed the bizarre reason why Ronaldo will not be playing against Croatia.
"I am very doubtful that he will be 100 per cent OK," Santos said.
"He had been training well, then suddenly on Wednesday one of his toes was red, as if he'd been stung by a bee.
"Now we have to wait. With an infection, you don't know how long the recovery is going to take."
Ronaldo is chasing his 100th goal for Portugal and sits on 99.
It would also have been his 165th cap for his national side - a record amount, with Luis Figo sitting second on 127.
The strange injury will mean the ex- Real Madrid star will have to wait until September 8 to get the chance to score his 100th goal.
Portugal face Sweden next in the Nations League prior to the restart of Serie A.
Juventus will kick off their title defence against Sampdoria on September 20.
Get the latest transfer news straight into your inbox!
Want to be on the ball with Jadon Sancho to Manchester United updates? Or perhaps you're a Chelsea fan wondering who on earth could join next?
Well then sign up for the brilliant new Daily Star Sport email newsletter!
From the latest transfer news to the agenda-setting stories, get it all in your email inbox.
How do you sign up?
It only takes a matter of seconds.
Simply type your email address into the box at the top of this article and hit 'subscribe'.
And that's it, job done. You'll receive an email with all of the top news stories every single morning.
You can find out more information on our email newsletter on this link here.
Maurizio Sarri was sacked after they were knocked out of the Champions League at the hands of Lyon.
Despite winning the title, it was not enough for the ex- Chelsea manager to keep his job.
Andrea Pirlo has been appointed as first-team coach despite having no experience as a manager.