Back at Old Trafford after impressing on loan at Sheffield United, the 23-year-old has vowed to depose the Spain star as Ole Gunnar Solskjaer’s top dog.
Henderson, who is currently with the England squad preparing to face Iceland, has just signed a new contract at United and believes his time is now.
He said: “David de Gea has obviously been a great goalkeeper first and foremost for many years and he's been phenomenal.
“That’s something I aspire to be, to have a career like him at the club so I'll be going back in first day of the pre-season working my socks off to get in that starting line-up.
“It's something I've always wanted. I'm so close now so I'm not going to give up now. I'm going to put the pressure on. I respect David.
“He’s been a phenomenal servant for the football club. If not one of the best in the recent years. It's down to me. I know what challenges are going to be ahead. I’m well up for it.”
Henderson also has his sights set on one day being England boss Gareth Southgate ’s No.1 - but knows he needs regular games just to stay in the squad.
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He said: “Yes. 100%. I accept that. The aim is for me to play football next season. I don't want to be not playing after last season coming off a good season with momentum.
“It wouldn't be clever for me to sit around and not play football, I don't think it would help any parties at all.
“I'm working hard every single day to do what I can do to class as Garerth’s number one but I know I've got to get past two very good goalkeepers.”