The non-league minnows, who play in the eighth-tier of English football, welcome Jose Mourinho’s side in the third round of the competition.
Marine have already had to win six matches to get to this stage, starting their FA Cup run back in September.
They shocked Colchester United in the first round before seeing off fellow non-league side Havant & Waterlooville.
That set up a dream tie with Tottenham, and Betfair are expecting it to be a simple evening for the Premier League giants.
They have Northern Premier League Division One North West outfit Marine at 80/1 to shock Tottenham and the footballing world.
The bookmakers have listed 13 things more likely to happen, including former Manchester United and Liverpool striker Owen to be next England manager.
That’s 75/1, while Jurgen Klopp being next to take over as Three Lions boss is at 40/1.
Away from football, heavyweight world champion Tyson Fury is more likely to win the WWE Royal Rumble this year than Marine are to beat Tottenham.
Spurs star Toby Alderweireld knows his side are in a ‘no win’ situation, saying: “You can't really win the game. If you win, you're expected to.
“So it's pressure but it is good to have pressure — if you have no pressure, you are a little bit sloppy.
“Everyone expects us to win easily but it's never that easy because, for most of those guys, it's the game of their lives, so they're going to do everything to make it as difficult as possible.
“It's up to us to start well and give a good level of performance. If we put the same work rate in as them then, of course, quality will beat them.”
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Things more likely to happen than Marine beating Spurs - football
James Milner to be next Liverpool manager: 25/1
Manchester United to be Pep Guardiola's next club he manages: 33/1
Jurgen Klopp to be next England manager: 40/1
Jack Grealish to win Sports Personality of the Year 2021: 50/1
Leicester to win the Premier League and FA Cup double this season: 50/1
Newcastle United to finish rock bottom this season: 55/1
Manchester United to finish in the bottom half this season: 60/1
Michael Owen to be next England manager: 75/1
Things more likely to happen than Marine beating Spurs - sports & current affairs
Jeremy Corbyn to appear on I'm a Celebrity 2021: 33/1
Nigel Farage to be the next Prime Minister after Boris Johnson: 40/1
Meghan and Harry's son Archie to become a train driver: 50/1
James Corden to be the next Doctor Who: 50/1
Tyson Fury to win men’s WWE royal rumble in 2021: 60/1
Odds according to Betfair