The Europa League gave Solskjaer the chance to hand minutes to those who were not at the top of the pecking order, but it is unlikely he will be willing to take the same risks at the highest level.
The likes of James Garner, Dylan Levitt, Matej Kovar and Ethan Laird are set to join lower league outfits, which could help them gain the experience they need to make it in the top flight.
According to Goal, there will be notable outgoing deals at United after a series of discussions.
Garner, 19, is said to have attracted the interest of Swansea City and Sheffield Wednesday having made six appearances under Solskjaer in all competitions in the 2019/20 season.
They add that the central midfielder, who scored nine goals in 12 appearances from midfield for the Under23 side, is ready for a big challenge away from Old Trafford.
Fellow midfielder Levitt, also 19, who impressed on his debut against Astana in November, is also set for a move away and he has also been linked with a drop down to the Championship.
Goalkeeper Kovar, 20, is yet to make an appearance for the first-team and he will slip further down the pecking order when Dean Henderson returns from Sheffield United - which is likely to see him leave on loan.
Laird, 18, impressed at riga-back against Astana last year, and is said to be the subject of plenty of loan inquiries.
He has been training with the first-team but looks unlikely to get much playing time should he choose to stay at Old Trafford.
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When asked about his summer transfer plans, Solskjaer said last month: “If you look at the table, we’re nowhere near where we should be.
“Consistency has to be improved and we still have to improve on many aspects of the game.
“There’s definitely not going to be any complacency and thinking, ‘We’ve cracked it’ because we’ve got so much to do. It’s an enjoyable journey.
"We can see improvements but, yes, we need to make one or two - or more - very good decisions. It’s going to be an important summer, definitely.”