The news that Liverpool defender Virgil van Dijk could be out for the season as he prepares to undergo surgery on his knee after suffering an anterior cruciate ligament injury in the Merseyside derby clash with Everton will be a major blow to their hopes of retaining the Premier League title.
However, Jurgen Klopp's men have received some good news, with goalkeeper Alisson Becker reportedly ahead of schedule in his recovery from a shoulder injury and Thiago Alcantara thought to have avoided a serious knee problem of his own.
The Athletic are reporting that summer signing Alcantara will not be along-term miss after he was the victim of a horror challenge from Richarlison in the derby.
The Spaniard is expected to miss the Champions League clash with Ajax on Wednesday but could be back in action soon.
The report also states that Alisson's recovery from a shoulder problem has progressed well, with the Brazilian expected to return to training imminently, and he could be back in between the sticks before the end of October.
Speaking ahead of the derby, Klopp was positive about Alisson's rehabilitation.
He said: "Very, very positive with Ali. It looks really good. He has made big steps. I don't have a timeframe but it looks really good."
Van Dijk will be tough to replace in the heart of defence, with Joe Gomez and Joel Matip the only senior centre-back options remaining after the sale of Dejan Lovren to Zenit St Petersburg earlier this summer.
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Defensive midfielder Fabinho may well drop back into the back four, as he did so successfully in the 2-0 win over Chelsea earlier this season.
Speaking immediately after the 2-2 draw with Everton, Klopp admitted Van Dijk's injury was "not good", saying: "Virgil played I don't know how many games in a row, he plays with pain but he couldn't play on and that's not good."