The international break got off to a disastrous start for Liverpool with Joe Gomez's injury - while six other Reds stars were also in action for their countries on Wednesday night.
Gomez added to the Premier League champions' defensive injury crisis after suffering suspected knee ligament damage in training with England.
The 23-year-old is now expected to be out for several weeks - if not longer - and joins right-back Trent Alexander-Arnold on the sidelines, with defensive lynchpin Virgil van Dijk already ruled out for most of the season.
There were better fortunes for some of Jurgen Klopp's other players as the international action got underway on Wednesday, with European sides playing friendlies ahead of their forthcoming Nations League fixtures, while Africa Cup of Nations qualifiers were also taking place.
Georginio Wijnaldum stood in for Van Dijk to captain the Netherlands for the first half of their 1-1 friendly draw with Spain in Amsterdam, before being replaced at the interval by Ajax star Davy Klaasen.
Xherdan Shaqiri was introduced at half-time with Switzerland holding Belgium, but couldn't prevent his side losing 2-1 to the world's top-ranked team at Den Dreef in Leuven.
Diogo Jota played the final 16 minutes for Portugal against Andorra at Benfica’s Estadio da Luz. The hosts were four up when Jota came on, and went on to record an emphatic 7-0 win against the minnows.
Kostas Tsimikas played the first half of Greece’s 2-1 win over Cyprus, having so far had just three minutes on the pitch for Liverpool since joining in the summer.
The hosts won 2-1 in Athens after racing into a two-goal lead inside the first 18 minutes.
In Africa Cup of Nations qualifying, Sadio Mane scored a penalty on the stroke of half-time to help Senegal beat Guinea-Bissau 2-0 in Thies, while Naby Keita captained Guinea to a 1-0 victory at home to Chad.
The likes of Jordan Henderson, Andy Robertson and Neco Williams could be in action on Thursday with England, Scotland and Wales all playing.
And everyone at Anfield will be desperately hoping there are no more injuries for Klopp's players ahead of Liverpool's next Premier League game at home to leaders Leicester on November 21.