All 20 top flight clubs will get together on Wednesday for a shareholders meeting that promises to be one of the most hostile in history.
And both Liverpool and United are now bracing themselves for a furious backlash from rival clubs - after it emerged the English giants are behind controversial plans for the biggest overhaul the sport has seen in almost 30 years.
"Project Big Picture" includes plans to reduce the Premier League to 18 teams, hand over controlling power to the most influential clubs in the top flight and provide the EFL with a £250m bailout following the Covid-19 crisis.
The nine clubs who have been in the Premier League the longest - which includes the big six of United, Liverpool, Chelsea, Manchester City, Arsenal and Tottenham - would also run every aspect of the richest league in the world and be given "long-term shareholder status" allowing them to vote on sweeping changes and even be able to veto a new owner taking over a rival club.
But it is understood the remaining 14 clubs in the top flight have no intention of backing the plans - and will unleash their fury on those behind the idea.
Those in opposition are not prepared to give up the 'one club, one vote' rule.
It has also emerged some clubs didn't even know about the proposals, while Premier League chief executive Richard Masters has been left seething after EFL chairman Rick Parry went public with the bombshell news without telling him.
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Parry's plans are now in danger of collapsing as football finds itself in a full blown civil war. EFL chief executive David Baldwin has resigned less than six months after taking the job, but insisted last night his decision had nothing to do with events of the last 48 hours.
Meanwhile an official spokesman for Prime Minister Boris Johnson blasted "Project Big Picture" and accused it of "undermining the trust in football's governance."