Both Riyad Mahrez and Aymeric Laporte have tested positive for coronavirus in a major blow to Manchester City.
The pair are self-isolating and following the necessary protocols, and it is unclear when they will be back in action for Pep Guardiola's side.
A statement on City's website read: "Manchester City FC can confirm that Riyad Mahrez and Aymeric Laporte have tested positive for Covid-19.
"Both players are currently observing a period of self-isolation in accordance with Premier League and UK Government protocol on quarantine. Neither is displaying symptoms of the virus.
"Everyone at the Club wishes Riyad and Aymeric a speedy recovery ahead of their return to training and the new season."
City’s first game of the season at home to Aston Villa has been postponed and is yet to be rescheduled.
That was moved after City’s 2019/20 campaign was prolonged due to them competing in the Champions League in August.
As a result, they may not play until Monday, September 21 when Guardiola’s men are due to travel to Wolves.
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Laporte and Mahrez could potentially be available by then as their period of self-isolation should be completed by then.
Guardiola does have other options in attack to choose from if he is without Mahrez for the beginning of the 2020/21 campaign.
However, losing star centre-half Laporte will be an issue, given their problems at the back last term.
City's signing of Nathan Ake this summer does help them in that department, though.
And Guardiola's side are still chasing the services of Napoli star Kalidou Koulibaly.
He could yet arrive at the Etihad before the October 5 transfer deadline if a deal can be agreed with the Serie A club.