United head to Anfield on Sunday, looking to take a firm grip on the title race after leapfrogging the champions in midweek.
The win over Burnley on Tuesday, saw Ole Gunnar Solskjaer’s men occupy top spot after 18 games for the first time since Sir Alex Ferguson’s retirement.
And they can take another little step towards a first title since in 2013, with a win over Jurgen Klopp’s side.
But going into the game on Merseyside, Solskjaer has a number of injury concerns to key first-team players.
In the win at Turf Moor, Martial hobbled off in added time after suffering an apparent hamstring injury, while Matic seemed to have suffered a groin issue in the closing minutes.
Lindelof was ruled out altogether as his lingering back problem continues to limit his appearances.
Eric Bailly did start the game however, despite picking up a knock of his own in the FA Cup third round clash with Watford.
The central defender was taken out of the action before the half-time break, after being involved in a heavy collision with United stopper Dean Henderson.
Solskjaer revealed after the win over the Clarets, that it was Bailly who made his case to start in the 1-0 victory.
“He wanted to play, he was ready, he came through [training] yesterday, he didn't do everything but he was ok. Victor had a little reaction so we left him back," Solskjaer said.
Meanwhile, Liverpool have a number of injury concerns of their own to contend with.
The champions have been ravaged by defensive injuries this season, with first choice pairing Virgil van Dijk and Joe Gomez out for significant portions of the season.
Joel Matip has stepped in on occasions, but has had his own fitness concerns and is a major doubt for the visit of the Red Devils.
The former Schalke man picked up an adductor strain in December’s win over West Brom and after missing training on Wednesday, is now in a race against time to be fit for the weekend.
Central midfielders Jordan Henderson and Fabinho have been forced to shuffle back in defence, leaving them short of bodies in the centre of the park.
That problem could be exacerbated even further by Naby Keita, who was also absent for Liverpool’s latest session.