The Serbian international won five domestic titles and a Champions League in his 300 appearances for the Red Devils.
Named Premier League player of the season twice at United, the 38-year-old earned a reputation as one of the best defenders to grace English football.
But Vidic has now named the most difficult opponents he has faced in the top flight.
Speaking to The Athletic, the former defender said: “My first experience was Peter Crouch.
“I’d never seen a two-metres tall player before. He played for Liverpool and we played them in a cup game at Anfield. I was thinking ‘Wow, what can I do today with this guy’.
"Then I saw Bellamy next to him, not a great player on the ball but very, very fast.
“He would run into space, Crouch would jump into the air. I’d never seen football played like this.
"I’d never had a No 9 and a sharp, fast, player next to him. I knew how to deal with them individually but not both of them at the same time. I played alongside Wes Brown, it was a tough game, a long game. We lost 1-0.”
Chelsea’s legendary forward Didier Drogba, who scored 104 top-flight goals at Stamford Bridge, also made Vidic’s list.
The former defender continued; “He was a very clever player who would get into the brain of the defenders. He was strong, but he was always thinking ahead.
"He would think, ‘If the defender pushes me now I will go down’ or ‘Next time I will go strong’.
"He scored so many important goals, he was very consistent. I played against him when we were both at the peak of our careers.”
While the rest was made up by Manchester City forward Sergio Aguero, fourth on the all-time top Premier League scorer list with 180, and former Liverpool man Luis Suarez, who came close to winning the title in the 2013/14 season.
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“I’m convinced that Aguero was born as a defender. He knows where the ball will come and where he can attack,” he continued.
"I played against him when they beat us 4-1 in the Moyes season.
“[Suarez is] an energetic player. He’s different from Aguero who doesn’t run for 90 minutes - he’s a player who uses instinct. Everything is done in bursts. I don’t think he knows exactly what he’s doing but he succeeds.
“The ball will go through a defender’s legs and people will think it’s an accident, but he has this sheer force to do it."