William Saliba has returned from his loan at Saint-Etienne and the Gunners have forked out more than £20m to sign Gabriel Magalhaes from Lille, meaning Arteta has a wealth of options at his disposal.
Arteta ended last season favouring a system which utilised three centre-backs and wing-backs and continued with the same system in Arsenal's penalty shoot-out win over Liverpool in the Community Shield curtain raiser.
If he continues in the same fashion then David Luiz will likely occupy the central defender role.
On the right of defence will be Saliba, while left-footed centre-backs Magalhaes and Pablo Mari will compete for the other spot.
However, Arteta is believed to favour a 4-3-3 formation going forward, with Magalhaes and Saliba believed to be his favoured pairing.
The duo are new to the Premier League though, so it would be no surprise to see him persist with the back three while they get acclimatised to English football.
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Hector Bellerin and Kieran Tierney will be his first-choice full-backs in either system but that depends on whether or not Bellerin leaves the club this summer.
Paris Saint-Germain have been linked with the Spaniard and Gunners legend Charlie Nicholas has claimed the club should sell him if they get the right offer.
Speaking to Sky Sports, Nicholas said: "I would contemplate and look at, people have been mentioning, somebody like Bellerin if the right money came.
"Now, Bellerin has been a star but since his bad injury he's never really recovered fully. If we can get him fit again and get him going again, then I'm all for Bellerin staying here."
If Bellerin does depart then Ainsley Maitland-Niles may continue as a makeshift right-back after impressing in the role, despite talk that he could also be sold.