Reguilon’s social media activity from eight years ago, though, suggests that the north London side always had an advantage because of manager Jose Mourinho.
The current Spurs manager’s name were the only two words in a tweet by the Spaniard dated January 25 2012.
It came hours before the Portuguese manager tasted defeat the youngster’s side Real in a dramatic 2-2 draw against Barcelona in the Copa del Rey, losing the tie 4-3 on aggregate.
At the time, a 15-year-old Reguilon was working his way up the ranks in the Bernabeu academy, arriving in 2005 from EFM Villalba.
It was one of the 23-year-old’s first posts on the social media channel, having joined in 2011.
But it has now been liked more than 6,000 times as the Spurs faithful made their feelings clear about speculation he could arrive in north London.
“Mourinho’s pulling power is the best in the world,” one supporter said.
Another commented: “He already knew the chosen one - couldn’t say no.”
While a third came up with a theory, saying: “Can imagine Jose has spoken to the guy. Told him the problems at United and convinced to move to London!”
And a fourth simply added: “Jose in Number One!”
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Spurs have also held tentative talks about a loan move for Gareth Bale but Real would have to carry on paying a big portion of his salary for that to happen.
Speaking to The Times, team-mate Luka Modric said: "For almost 12 years we are playing together and it’s a difficult situation for him and for the club.
“Does he feel happy here or does he want to try something else? But, for me, Gareth is still a great player and still has a lot to offer in football.
"It just depends on him, if he has enough hunger or desire to keep going. I think he has but whether his situation finishes here or continues, he can still be an important player.”