Virgil van Dijk’s injury has changed things drastically for Liverpool - and Manchester United could also feel the impact.
Both Liverpool and United were linked with a dip into the transfer market to strengthen their central defensive options in January.
Whilst it was viewed as a greater need for United to strengthen their first-team, it is Liverpool who are now paying the price for their failure to replace Dejan Lovren.
With Van Dijk set for knee surgery and facing a battle to play again this season, they are thin on the ground at the heart of defence.
That means it now looks likely they could dip into the transfer market in January for a replacement.
And Dayot Upamecano, linked with a move to Old Trafford next summer, could well be the logical replacement if they can tempt RB Leipzig to sell.
United and Liverpool have been linked with several of the same defenders, including Upamecano.
But Liverpool may now steal a march on their rivals in the transfer market as they begin working to identify Van Dijk’s replacement to act quickly in January.
Upamecano, who will have a new £36 million release clause come into effect next summer, might be hard to obtain in January.
The likes of Kalidou Koulibaly and Diego Carlos have also been linked with both clubs.
And, the likelihood is, if United turn to a defender in January then they may have to compete with Liverpool for their signature.
That will be a tough task for Ole Gunnar Solskjaer, who is very much rebuilding his defence whereas Klopp has an established and well-oiled machine at work at Anfield.
If Liverpool turn to Upamecano in January and get their man, then that could well derail Solskjaer’s plans after reports he was keen to make him a priority target next summer.