Along with her co-host Phillip Schofield, the duo discussed unusually-shaped veggies after a British student shared a photo of his double-pronged banana online.
However, the wacky produce proved too much for Holly, 39, when a bulging sweet potato appeared on the screen.
With Phil branding the root vegetable as "wishful thinking," the co-hosts were left in stitches over its phallic shape.
Phil said: "Have a look at this next one and see whether you think this is real – or just wishful thinking."
Reading the comment from the viewer who sent the photo in, he added: "I asked my daughter to get a sweet potato this is what she found,’ says Rebecca."
Urging the ITV team to take it off-screen, Holly exclaimed: "I don’t know what to say about that. I can’t look at that any longer."
They then moved on to a hunk of pink ham, which had an unexpected frowny face carved into its meaty centre.
Holly read: "My dad’s piece of ham had an incredibly sad face."
Earlier in the segment, Holly shared a handy hack for cutting a banana, after the photo of the "double-barrelled" fruit appeared on the screen.
Looking at the snap of the hefty banana, Holly exclaimed: "It's got some girth on it, I'll give him that."
Student Tom Symes bought a banana in his local Tesco, only to discover it had two fingers inside the skin.
Holly was convinced Tom might have simply sliced the banana in half, as she sliced the fruit open with a cocktail stick.
Urging Tom to get in touch, Holly announced: "We need more evidence!"
This Morning airs on weekdays at 10am on ITV.