However just moments into the honest chat, the boxer disappeared from the screen with his camera instead showing a view of his ceiling.
Phil and Holly were surprised and asked if everything was alright, with Tyson laughing: "It's on a table, but I hit the table with my big hands."
Tyson, 32, continued on with his chat, but he knocked his camera again towards the end, sending it spinning off the table.
Phil, 58, joked: "He's gone again! He's gone again! Another knock out!"
While Holly, 39, laughed: "This is my favourite chat we've ever done."
During the segment, Tyson opened up about his mental health battle, which saw him contemplate suicide at his darkest points.
He explained: "I was out on Halloween 2017 for a few drinks and I had a moment of sanity.
"I looked round me and saw college people, university people, and thought, 'These people are at the start of their careers hoping to go and do things, I'm in the middle of mine and thinking of ending it.'"
The sportsman went on: "I got home and I remember praying on my knees for help and the next morning I started to train, and I thought, 'If I'm ever gonna get well, I need to get back training, swap negative for positive feelings.'
"It wasn't an easy process, it took me about 18 months to start feeling right again, but it was well worth the journey," he finished.
For emotional support you can call the Samaritans 24-hour helpline on 116 123, email [email protected], visit a Samaritans branch in person or go to the Samaritans website.
This Morning airs weekdays at 10am on ITV