During Thursday's edition of GMB, hosts Kate Garraway and Alex Beresford were discussing if women prefer a 'dad bod' or a ripped man.
According to new data, women prefer less ripped men when it comes to guys in their 30s.
Wayne, 58, was booked on the show to defend six-packed men and insist they are not more likely to cheat than fluffier guys.
Meanwhile, actor Tamar Hassan was meant to wave pom-poms for dad bods.
However, it quickly became clear Wayne wasn't sure what he should say.
Looking bemused after Kate asked him for his take on the new data, Wayne said: "I'm not sure to be honest.
"Are we talking about what women want here... sorry?"
The O Beach owner added: "Fitter guys with better bodies get more temptation to distract themselves with.
"It doesn't matter what you look like.. once a cheater always a cheater it is something in your mindset."
Laughing, Tamar said: "Wake up son. He's probably been out all night."
He continued: "Listen I go to the gym a lot but I am not bothered about abs.
"Any man who concentrates on himself that much can't be trusted."
After Tamar explained to Wayne he should be defending ripped guys, Gary Lineker's brother continued: "Yeah, the guys with the fit body are going to get more attention.
"Fair enough they do need their egos fed more but I think this is life. They can be good dad's too."
Unable to contain their bemusement, Kate and Alex in the studio could be seen smirking away as the two men opened up.
Taking to Twitter, one viewer wrote: "Wayne Lineker doesn't know what he's on telly for.... Great start."
Another added: "Awful interview there with Wayne Lineker and the other bloke, couldn't string a sentence between them, terrible scenes."
A third continued: "Garraway looking confused and Hassan laughing that Lineker didn’t have a clue."
Good Morning Britain airs weekdays on ITV at 6am